Bupropion (Wellbutrin) was temporarily removed from the market after its initial release due to the occurrence of seizures in some patients. However, further investigation showed that seizures were primarily associated with high doses (above the current maximum recommended dose of 450 mg/day), a history of seizures or brain trauma, an eating disorder, excessive alcohol use, or taking other drugs that can also increase the risk for seizures. With new warnings and lower recommended doses, the chance of having seizures has been greatly reduced.
This potentially serious sleep disorder, in which the throat muscles intermittently relax and block the airway during sleep, affects around 50% of people with diabetes, Hamdy says, especially those who are obese and have a collar size of more than 17 for men and 16 for women. The most obvious sign of obstructive sleep apnea (OSA) is audible snoring. Unfortunately, like gum disease, "sleep apnea may worsen diabetes control," Hamdy says, possibly because the two conditions share risk factors. Also like gum disease, having OSA can suggest the possibility of future diabetes. A 2014 study in the American Journal of Respiratory and Critical Care Medicine found that severe OSA increases a person's risk of developing diabetes by 30% or more. Treatment for OSA may involve using a device to keep your airway open at night or wearing a mouthpiece that thrusts your jaw forward. In severe cases, surgery can help by altering the structure of the nose, mouth, or throat.